The Best Ergonomic Mouse for 2025


Trackballs, vertical mice, and odd sculptures: There are numerous ergonomic techniques for comfortable mousing. The shared goal is to reduce the risk of repetitive strain injuries that might result from spending a lot of time each day using a mouse and keyboard. However, choosing an ergonomic mouse can be challenging because there are so many different sizes, styles, and functionalities available. That's where our knowledge is useful.

Since the beginning of the Computers and laptops, Mighty PC has been testing and reviewing peripherals. We evaluate PC mice according to their features, design, comfort, connectivity, and (of course!) price. Our analysts have worked with many different types of models. Our best ergonomic mouse recommendation for the majority of users is the five-star rated Logitech MX Master 3S, but we also stand behind our other choices. Let's compare their pros and cons and learn how to choose the best ergonomic mouse.

9 Top Ergonomic Mice on the market

  1. Best Conventional Ergonomic Mouse: Logitech MX Master 3S Wireless Mouse
  2. Best Fingertip-Operated Trackball: Kensington Orbit Wireless Trackball
  3. Best Thumb-Style Trackball: Kensington Pro Fit Ergo TB550 Trackball
  4. Best Vertical Ergonomic Mouse: Lenovo Go Wireless Vertical Mouse
  5. Best Ergonomic Mouse for Accessibility: Microsoft Adaptive Mouse
  6. Best Ergonomic Mouse for Gaming: QuadraClicks RBT
  7. Best Ergonomic Mouse for Lefties: Goldtouch Semi-Vertical Wireless Mouse
  8. Best Ergonomic Mouse for Long Battery Life: Logitech Lift
  9. Best Ergonomic Mouse for Wrist Angle Adjustments: Contour Design SliderMouse Pro Wireless

Best Conventional Ergonomic Mouse: Logitech MX Master 3S Wireless Mouse

Logitech MX Master 3S Wireless Mouse review
The Logitech MX Master 3S Wireless Mouse is undoubtedly among the best available; it is quite comfortable despite not being an ergonomic mouse. The quiet buttons are snappy and gratifying, and the broad, curved design provides ample space for larger hands. This productivity king may not be the ideal option for people who have particular ergonomic concerns; in those situations, a rollerball or vertical mouse would be a better option. In contrast, the Logitech MX Master 3S is a mouse that is comfortable and reliable for both work and pleasure. If you're looking for an all-around mouse that excels in ergonomics and productivity, we highly recommend the Logitech MX Master 3S.

Where to buy: Check price at Amazon.

Read full review: Logitech MX Master 3S Wireless Mouse Review.

Pros and Cons

Pros

  • Remarkable comfort and battery life
  • Perfectly precise electromagnetic scroll wheel
  • Ultra-customizable for different apps
  • Works with multiple devices and operating systems

Cons

  • Lefties need not apply
  • No place to store the USB dongle
  • Fans of tactile clicks may prefer the older version

Configurations and Specs

  • Number of Buttons: 8
  • Interface: RF Wireless, Bluetooth
  • Hand Orientation: Right-Handed
  • Sensor Maker and Model: Logitech Darkfield
  • Sensor Maximum Resolution: 8000 dpi
  • Power Source: Internal Battery
  • Weight: 5 ounces
  • Warranty (Parts and Labor): 1 year

Best Fingertip-Operated Trackball: Kensington Orbit Wireless Trackball

Kensington Orbit Wireless Trackball with Scroll Ring
For those who want to avoid the wrist and finger strain that comes with regular mouse use, the Kensington Orbit Wireless Trackball ($49.99) is a straightforward and efficient ambidextrous trackball mouse. The Orbit demonstrates that it's a respectable portable choice as well with features like a detachable wrist rest, a distinctive scroll wheel, and Bluetooth and 2.4 GHz wireless connectivity. What therefore prevents us from promoting it without reservation? Compared to other thumb-operated trackballs, such as the Kensington Pro Fit Ergo TB550, we simply didn't find it as pleasant.

Design and build

Each trackball in Kensington's lengthy history has a unique design that occasionally makes or breaks the mouse's viability. A red, medium-sized trackball sits in the middle of the Orbit's small design, which also includes a scroll wheel that encircles the trackball's base and two clickers. IIt resembles a combination of the Expert Mouse Wireless Trackball and the Kensington SlimBlade Pro, but it leans more towards the latter. The Orbit, on the other hand, has a wider shape with a small tail at the end to support your wrists in place of the mouse's flat, square body.

Where to buy: Check price at Amazon.

Read full review: Kensington Orbit Wireless Trackball with Scroll Ring review.

Pros and Cons

Pros:
  • 2.4GHz and Bluetooth connectivity
  • Well-designed scroll wheel
  • Detachable wrist rest
  • Affordable

Cons:

  • Not comfortable to use without the wrist rest
  • No rechargeable battery
  • Build quality feels cheap

Specs and Configurations

  • Number of Buttons: 2
  • Interface: Bluetooth, 2.4GHz Wireless
  • Hand Orientation: Ambidextrous
  • Sensor Maker and Model: Unspecified Optical Sensor
  • Sensor Maximum Resolution: 1600 dpi
  • Power Source: Two AA Batteries
  • Weight: 5.6 ounces
  • Warranty (Parts and Labor): 3 year

Best Thumb-Style Trackball: Kensington Pro Fit Ergo TB550 Trackball

Kensington Pro Fit Ergo TB550 Trackball

The Kensington Pro Fit Ergo TB550 Trackball combines the versatility of a trackball with the comfort of a standard mouse to create a daily driver that is gentle on your hands and eyes. The Kensington Pro Fit Ergo TB550, which uses the right thumb for navigation rather than the fingers, reduces the trackball learning curve in half thanks to its form, which is typical of a conventional mouse. (I apologize; those who are left-handed will need to search elsewhere.) Additionally, the strong construction will prevent undesired cursor motions and keep your hand steady.

The Kensington Pro Fit Ergo TB550 Trackball is a great option for those who are interested in trackball mice but don't want to deviate too much from the well-known design of their existing computer mouse.

Read full review: Kensington Pro Fit Ergo TB550 Trackball.

Pros and Cons

Pros:

  • Comfortable to use
  • Excellent build quality
  • Plenty of functionality
  • 128-bit AES encryption

Cons:

  • Takes some getting used to
  • No left-handed option

Configurations and specs

  • Number of Buttons: 5
  • Interface: Bluetooth, USB Wired, 2.4GHz Wireless
  • Hand Orientation: Right-Handed
  • Sensor Maker and Model: Unspecified Optical Sensor
  • Sensor Maximum Resolution: 1600 dpi
  • Power Source: Internal Battery
  • Weight: 4.9 ounces
  • Warranty (Parts and Labor): 3 years

Best Vertical Ergonomic Mouse: Lenovo Go Wireless Vertical Mouse

Lenovo Go Wireless Vertical Computer Mouse

There are many different sizes and designs of ergonomic mice. While some, like the Lenovo Go Wireless Vertical Mouse, are as tall as they are comfortable, others maintain a modest profile. This mouse has an attractive, small form factor and a grip-enhancing cork substance. This mouse's lack of Bluetooth connectivity limits some of its functionality, necessitating the use of a USB dongle as a wireless tether. Nevertheless, the Lenovo Go prioritizes comfort, making it a strong wireless daily driver.

A vertical mouse, such as the Lenovo Go, can be the best choice for you if you're interested in ergonomics but are afraid of the trackball's learning curve.

Where to buy: Check price at Amazon.

Read full review: Lenovo Go Wireless Vertical Mouse.

Pros and Cons

Pros:

  • Corkboard material is comfortable
  • Stylish, compact modern design
  • Vertical grip is comfortable for long periods of use
  • DPI button
  • Built-in dongle storage

Cons:

  • Expensive given build quality
  • Lacks rechargeable battery
  • Needs dongle to pair to any device

Specs and Configurations

  • Number of Buttons: 5
  • Interface: RF Wireless
  • Hand Orientation: Right-Handed
  • Sensor Maker and Model: Unspecified Logitech Optical Sensor
  • Sensor Maximum Resolution: 2400 dpi
  • Power Source: One AA Battery
  • Weight: 0.21 pounds
  • Warranty (Parts and Labor): 1 year

Best Ergonomic Mouse for Accessibility: Microsoft Adaptive Mouse

Developed with the needs of people with disabilities in mind, the Microsoft Adaptive Mouse is a modular mouse that can be adjusted to meet your unique requirements. It is essentially a straightforward puck; the user must install adaptive accessories, which can be 3D printed if they have access to a 3D printer or bought from Microsoft. It is admirable that Microsoft made an attempt to develop a flexible system for users who are unable to use a conventional mouse or who merely wish to design their own unique input device. The Microsoft Adaptive Mouse is one step toward universally accessible technology, which is a human right. The Microsoft Adaptive Mouse is a special modular mouse that fits a variety of use cases, whether you're looking for a productivity powerhouse or are simply differently abled.

Where to buy: Check price at Amazon.

Read full review: Microsoft Adaptive Mouse for Business

Pros and Cons

Pros:

  • Inclusive design philosophy
  • Highly compact
  • Ambidextrous body design
  • Can be augmented by many 3D-printed accessories

Cons:

  • Needs accessories to work as intended
  • 3D printed accessories are pricey
  • Microsoft Accessory Center is Windows-exclusive

Specs and Configurations

  • Number of Buttons: 3
  • Interface: Bluetooth, USB Wired
  • Hand Orientation: Ambidextrous
  • Sensor Maker and Model: Sensor Maximum Resolution 6000 dpi
  • Power Source: Internal Battery, Wired USB
  • Weight :1.6 ounces
  • Warranty (Parts and Labor): 1 year

Best Ergonomic Mouse for Gaming: QuadraClicks RBT

Carpal Tunnel Solution Mouse QuadraClicks RBT Ergonomic Gaming Rabbit Protect Hand Safe Click Pain Arthritis Wrist Pain CTS FSA Approved

While there are several ergonomic office mice available, very few are made specifically for gaming. An uncommon exception is the QuadraClicks RBT. The RBT's unusual design and steep learning curve may initially intimidate you, but it will reduce stress once you get used to it. By clicking with the bottom of your fingers rather than your fingertips, the RBT aims to reduce strain. Although it's an expensive palm pleaser, it's well worth the time and work, particularly if you value hand comfort and safety. The QuadraClicks RBT is a more-than-capable tool for gamers seeking an ergonomic substitute for a typical gaming mouse.

Where to buy: Check price at Amazon.

Read full review: QuadraClicks RBT gaming mouse review.

Pros and Cons

Pros:

  • Innovative, comfortable design
  • Fast, responsive sensor
  • Unique ergonomics
  • Can be reimbursed by some health insurance plans

Cons:

  • Expensive
  • Software is Windows-only
  • Takes some getting used to

Configurations and Specs

  • Number of Buttons: 6
  • Interface: USB Wired
  • Hand Orientation: Ambidextrous
  • Sensor Maker and Model: Pixart PWM 3336
  • Sensor Maximum Resolution: 10700 dpi
  • Power Source: Wired USB
  • Weight: 3.7 ounces
  • Warranty (Parts and Labor): 1 year

Best Ergonomic Mouse for Lefties: Goldtouch Semi-Vertical Wireless Mouse

Why not try the Goldtouch Semi-Vertical Wireless Mouse instead of committing to a complete 90-degree tilt? The preference for vertical mice is subjective. The mouse's 66-degree tilt makes it a comfortable compromise between the normal and vertical mouse designs. Additionally, a detachable plastic hand rest is a distinctive item. The rest does give the already huge mouse a little more bulk. However, up to four 5-gram weights are included and can be added or removed to change the mouse's weight. Additionally, it comes in left-handed and right-handed varieties.

Overall, the Goldtouch serves as a versatile and comfortable choice for individuals who are not yet prepared to transition to a fully vertical mouse. The Goldtouch Semi-Vertical Wireless Mouse might be the finest alternative if you're not quite ready to consider switching from a vertical mouse, especially if you're seeking a left-handed option.

Where to buy: Check price at Amazon.

Read full review: Goldtouch Semi-Vertical Wireless Mouse review.

Pros and Cons

Pros:

  • Comfortable ergonomic shape
  • Detachable hand rest
  • Strong battery life
  • Left-handed model available

Cons:

  • Vertical mice are hard to use accurately
  • Low max DPI

Specs and Configurations

  • Number of Buttons: 6
  • Interface: RF Wireless
  • Hand Orientation: Left- and Right-Handed Models Available
  • Sensor Maker and Model: Pixart PAW3205
  • Sensor Maximum Resolution: 1600 dpi
  • Power Source: Two AA Batteries
  • Weight: 4.6 ounces
  • Warranty (Parts and Labor): 1 year

Best Ergonomic Mouse for Long Battery Life: Logitech Lift Vertical Ergonomic Mouse

Logitech Lift Vertical Ergonomic Mouse

The Logitech Lift is a multipurpose vertical mouse. It is a flexible tool for working at home or in the office because of its vibrant colors, long-lasting battery, and silent buttons. The Lift's compatibility with Logitech's Flow technology, which enables you to connect to many devices at once and transfer files between them with ease, makes it the perfect option for ergonomic PC and Mac control. Its small size and buttons that provide little feedback are its sole significant drawbacks. All things considered, the Logitech Lift provides comfort and style at a reasonable cost. Do you need a comfortable and stylish vertical mouse? You only need to consider the Logitech Lift.

Where to buy: Check price at Amazon.

Read full review: Logitech Lift Vertical Ergonomic Mouse review.

Pros and Cons

Pros:

  • Handsome, compact vertical design
  • Available in version for lefties
  • Rated 24-month battery life on one AA cell
  • Can seamlessly swap connections among up to three devices
  • Compatible with macOS

Cons:

  • Not comfortable for larger hands
  • Shallow switches offer little feedback

Configurations and Specs

  • Number of Buttons: 5
  • Interface: RF Wireless, Bluetooth
  • Hand Orientation: Right-Handed (version available for left-handed)
  • Sensor Maker and Model: Logitech Advanced Optical Tracking
  • Sensor Maximum Resolution: 4000 dpi
  • Power Source: Internal Battery
  • Weight: 0.27 pounds
  • Warranty (Parts and Labor): 1 year

Best Ergonomic Mouse for Wrist Angle Adjustments: Contour Design SliderMouse Pro Wireless

Contour Design SliderMouse Pro Wireless Ergonomic Mouse

A unique two-handed mouse, the Contour Design SliderPro Wireless is arguably the most innovative option on our list. The concept? For website navigation, use one hand for the slider and the other for the buttons and scroll wheel. The sliding bar allows for precise cursor movement, and the wide wrist rest provides plenty of comfort. When it clicks, you'll discover a beautifully unique ergonomic mouse for one or both hands. However, it will take some brain rewiring to make sense of using both hands to coordinate your actions. For those seeking an ergonomic mouse that prioritizes wrist support, the Contour Design SliderPro Wireless is a comfortable option.

Where to buy: Check price at Amazon.

Read full review: Contour Design SliderMouse Pro Wireless review.

Pros and Cons

Pros:

  • Easier to use than the RollerPro
  • Ambidextrous
  • Compatible with Macs
  • Customizable wrist rest
  • Comfortable slider bar

Cons:

  • Expensive
  • Risers not attached to the mouse
  • Steep learning curve
  • Takes up significant desk space

Specs and Configurations

  • Number of Buttons: 6
  • Interface: Bluetooth, USB Wired, 2.4GHz Wireless
  • Hand Orientation: Ambidextrous
  • Sensor Maker and Model: Not Applicable
  • Sensor Maximum Resolution: 2800 dpi
  • Power Source: Internal Battery
  • Weight: 2.15 pounds
  • Warranty (Parts and Labor): 2 years

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